Hi,
you can use Excel Interrop with CPython3/PythonNet but need to cast each object to the correct Interface
a small example here
for OpenXML, you can find many examples in GitHub in C# (but the portage to Python is not simple)
https://github.com/search?l=C%23&q=OpenXml+CellReference&type=Code
I understand the argument, but if you can, take a look at the Python libraries pandas and openpyxl
you can also install the IronPython package