Hi all!
After a fast support conversation and some testing i can conclude the folowing:
The bug lies somewhere with generative design, since i never had spickle installed in the first place.
I don’t exclude that pickle can also cause some issues ofcourse.
After deleting the Generative Design addin all worked fine again.
Updates and clearling temp-files didn’t help.
PS.: i first delete de GD-dll’s themselfs and that didn’t fix it, it was the GD-addin folder that is neede to delete to fix it.
I hope that the generative design-team gets word of this and goes for a bug-hunt 
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The funny thing was that the support team redirected me to this forum post 
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so i think there is not much knowledge about this yet.
For now i can’t use generative design wich is a hard bummer and i hope we can find some work around for that 
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Since i’m building some early-design analyses for ecologie this is a big part of my utilyset gone now for revit 2023 atleast…