You should be able to create a custom Python script node that can launch AutoCAD.
Add these lines:
import subprocess
subprocess.check_call([r"C:\Program Files (x86)\Mozilla Firefox\firefox.exe"])
If you want to open a specific file:
subprocess.check_call([r"C:\Program Files (x86)\Mozilla Firefox\firefox.exe",“https://www.google.com”])
You can make the filename a variable and pass that to the node if you want.
Good luck!