Unfortunately not out of the box. And as I understand this has been by design, although many have requested some sort of “Force Evaluation” functionality. (For instance for random generator nodes etc) The way many of the package makers have dealt with this is to feed the python node a boolean toggle and just not use it for anything in the script itself. However Dynamo will recognize when you have changed the boolean toggle and will therefore rerun the node. You can also try the “ForceChildrensEval” node from the Prorubim DS Common package as shown here: Help With Randomizing Placed Family Types? But I haven’t been able to get it to work with a python node… Maybe you’re in better luck! 
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