Oh, you can certainly access them (in the host doc only) and here is how it can be done with Python, i couldn’t seem to find a node for it so made one…
from RevitServices.Persistence import DocumentManager
from RevitServices.Transactions import TransactionManager
doc = DocumentManager.Instance.CurrentDBDocument
app = DocumentManager.Instance.CurrentUIApplication.Application
from Autodesk.Revit.DB import *
if hasattr(obj1,"__iter__"): return obj1
else: return [obj1]
val = int(val)
if val < 0: val = 0
if val >10: val = 10
# In Variables...
views = tolist(UnwrapElement(IN))
enabled = tolist(IN)
ext = tolist(IN)
jitter = tolist(IN)
# Out Variables...
outList = 
# Main Body...
for v in views:
vdsl = v.GetSketchyLines()
vdsl.EnableSketchyLines = enabled
vdsl.Extension = ClampValue(ext)
vdsl.Jitter = ClampValue(jitter)
outList.append("Failed:\n" + e.message)
OUT = outList
However, as mentioned, this can only set the sketchy lines of the actual doc it is run in (not a linked doc). Also, it really depends on whether Revit does not just override these in the host model you are linking into (if that makes sense).
As @JacobSmall mentions, you could also use view templates too. But i would conclude with, yes, it is possible to set sketchy lines. But i’m not sure this will help you.